Chemists Discover Why Synonymous DNA Mutations Are Not Always Silent – SciTechDaily


Illustration of a new class of protein misfolding called a non-covalent lasso entanglement that can result from changes to the rate of protein synthesis caused by synonymous mutations. Bottom: structure of a protein showing its native state and misfolded state with non-covalent lasso entanglement. Credit: Yang Jiang, Penn State

Modeling shows how genetic changes that don’t lead to changes in protein sequence can still alter protein function.

New modeling shows how synonymous mutations — those that change the DNA